Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis.
نویسندگان
چکیده
A voriconazole-resistant isolate of Aspergillus fumigatus was recovered from an immunocompetent patient receiving long-term antifungal therapy for cerebral aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was identified as the cause of the resistance phenotype. This article describes the first isolation of a voriconazole-resistant A. fumigatus isolate from an immunocompetent patient in Spain.
منابع مشابه
Resistance to voriconazole due to a G 448 S substitution in 4 Aspergillus fumigatus in a patient with cerebral aspergillosis
28 A voriconazole-resistant isolate of Aspergillus fumigatus was recovered from an 29 immunocompetent patient receiving long-term antifungal therapy for cerebral 30 aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was 31 identified as the cause accounting for the resistant phenotype. This article 32 describes the first isolation of a voriconazole-resistant A. fumigatu...
متن کاملMorphological changes and induction of antifungal resistance in Aspergillus fumigatus due to different CO2 levels
Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus (A. fumigatus) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2, we examined the effects of various...
متن کاملAspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole.
OBJECTIVES Voriconazole, itraconazole and posaconazole are members of the azole family and widely used for the treatment of aspergillosis. They act by inhibiting the activity of the fungal Cyp51A enzyme. The emergence of environmental azole-resistant Aspergillus fumigatus strains raises major concerns for human health. METHODS Recently, a new cyp51A-mediated resistance mechanism (namely TR46/...
متن کاملAspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles.
BACKGROUND Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases. Selection of azole resistance may occur through exposure to azole fungicides in the environment. In the Netherlands a surveillance network was used to investigate the epidemiology of resistance selection in A. fumigatus. METHODS Clinical A. ...
متن کاملLow prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.
OBJECTIVES An increase in invasive aspergillosis (IA) due to azole-resistant Aspergillus fumigatus isolates has been reported for 10 years. Our study aimed to estimate the prevalence of azole resistance in isolates prospectively collected in patients with haematological diseases. METHODS One hundred and eighteen isolates were collected from 89 consecutive patients over 4 years. Fifty-one pati...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 50 7 شماره
صفحات -
تاریخ انتشار 2012